Pan-cancer analysis for the prognostic and immunological role of CD47: interact with TNFRSF9 inducing CD8 + T cell exhaustion

Abstract Purpose The research endeavors to explore the implications of CD47 in cancer immunotherapy effectiveness.Specifically, there is a gap in comprehending the influence of CD47 on the tumor immune microenvironment, particularly in relation to CD8 + T cells.Our study aims to elucidate the prognostic and immunological relevance of CD47 to enhanc

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Genome Comparisons of Candida glabrata Serial Clinical Isolates Reveal Patterns of Genetic Variation in Infecting Clonal Populations

Candida glabrata is an opportunistic fungal pathogen that currently ranks as the second most common cause of candidiasis.Although the mechanisms underlying virulence and drug resistance in C.glabrata are now starting to be elucidated, we still lack a good understanding of how this yeast adapts during the course of an infection.Outstanding questions

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Plectin in Skin Fragility Disorders

Plectin is a multi-faceted, 500 kDa-large protein, which due to its expression in different isoforms and distinct organs acts diversely as a cytoskeletal crosslinker and signaling scaffold.It functions as a mediator of keratinocyte mechanical Scarves stability in the skin, primarily through linking intermediate filaments to hemidesmosomes.Skin frag

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